Tau protein as a differential biomarker of tauopathies
نویسندگان
چکیده
منابع مشابه
Tau protein as a differential biomarker of tauopathies.
Microtubule-associated Tau proteins are the basic component of intraneuronal and glial inclusions observed in many neurological disorders, the so-called tauopathies. Many etiological factors, phosphorylation, splicing, and mutations, relate Tau proteins to neurodegeneration. Molecular analysis has revealed that hyperphosphorylation and abnormal phosphorylation might be one of the important even...
متن کاملTau and tauopathies.
Tau protein is a neuronal microtubule-associated protein (MAP), which localizes primarily in the axon. It is one of the major and most widely distributed MAPs in the central nervous system. Its biochemistry and molecular pathology is being increasingly studied. Tau is a key component of neurofbrillary tangles in Alzheimer's disease (AD). Disorders with neuronal, oligodendroglial or astrocytic f...
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The microtubule-associated protein Tau is mainly expressed in neurons of the CNS and is crucial in axonal maintenance and axonal transport. The rationale for Tau as a biomarker of neurodegenerative diseases is that it is a major component of abnormal intraneuronal aggregates observed in numerous tauopathies, including Alzheimer's disease. The molecular diversity of Tau is very useful when analy...
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Tauopathies comprise a group of progressive age-associated neurodegenerative diseases where tau protein deposits are found as the predominant pathological signature (primary tauopathies) or in combination with the presence of other toxic aggregates (secondary tauopathies). In recent years, emerging evidence suggests that abnormal tau accumulation is mediated through spreading of seeds of the pr...
متن کاملTau as biomarker of neurodegenerative diseases
1. Inserm, U837, place de Verdun, 59045 Lille, France. 2. Université de Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France. 3. Institut de Biochimie, Centre hospitalier universitaire, UF de Neurobiologie, Lille, France. 4. Innogenetics NV, Industriepark Zwijnaarde 7, 9052 Gent...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2005
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2004.06.020